Science

At OncoBlaze, our innovative technology, grounded in peer-reviewed science, enables the delivery of high-dose chemotherapy with pinpoint accuracy to tissues harboring remnant cancer cells after surgery. This drug-device combination pairs a potent chemotherapeutic, encapsulated in heat-sensitive lipid particles, with a precision heating device. Upon mild heating, the lipid particles release the drug directly into targeted tissues. Additionally, our device features an integrated imaging system, allowing real-time visualization of the drug’s precise location and dosage. In preclinical sarcoma mouse models, this approach has shown over 80% efficacy in preventing tumor recurrence.

D Haemmerich, KK Ramajayam, DA Newton

Cancers 15 (2), 398, 2023

KK Ramajayam, DA Newton, D Haemmerich

International Journal of Hyperthermia 39 (1), 998-1009, 2022

A Motamarry, AM Wolfe, KK Ramajayam, S Pattanaik, T Benton, ...

Cancers 14 (5), 1322, 2022

TLM Ten Hagen, MR Dreher, S Zalba, ALB Seynhaeve, M Amin, L Li, ...

Communications Biology 4 (1), 920, 2021

KK Ramajayam, AM Wolfe, A Motamarry, GJ Nahhas, J Yost, MJ Yost, ...

IEEE open journal of engineering in medicine and biology 2, 187-197, 2021

A Motamarry, AH Negussie, C Rossmann, J Small, AM Wolfe, BJ Wood, ...

International Journal of Hyperthermia 36 (1), 816-825, 2019

C Burke, MR Dreher, AH Negussie, AS Mikhail, P Yarmolenko, A Patel, ...

International Journal of Hyperthermia 34 (6), 786-794, 2018

D Haemmerich

The Lancet Oncology 19 (8), 1000-1001, 2018

D Haemmerich, A Motamarry

Advances in cancer research 139, 121-146, 2018

AL Bredlau, A Motamarry, C Chen, MA McCrackin, K Helke, KE Armeson, ...

Drug delivery 25 (1), 973-984, 2018

C Rossmann, MA McCrackin, KE Armeson, D Haemmerich

PLoS One 12 (6), e0179131, 2017

A Gasselhuber, MR Dreher, F Rattay, BJ Wood, D Haemmerich

Public Library of Science 7 (10), e47453, 2012

A Gasselhuber, MR Dreher, A Partanen, PS Yarmolenko, D Woods, ...

International Journal of Hyperthermia 28 (4), 337-348, 2012